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Synthesis of Trisubstituted Acrylic Acids through Nickel‐Catalyzed Carbomagnesiation of Alkynes and Carbon Dioxide Fixation
Author(s) -
Hung ChenHsun,
Santhoshkumar Rajagopal,
Chang YuChe,
Cheng ChienHong
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801364
Subject(s) - chemistry , carboxylation , reagent , carbon fixation , alkyne , catalysis , nickel , acrylic acid , stereoselectivity , organic chemistry , grignard reagent , carbon dioxide , grignard reaction , combinatorial chemistry , copolymer , polymer
A nickel‐catalyzed synthesis of trisubstituted acrylic acids from alkynes, Grignard reagents, and CO 2 is reported. The reaction proceeds through carbomagnesiation of the alkyne with Grignard reagent followed by carboxylation with CO 2 under mild reaction conditions in short time. Various unsymmetrical alkynes were transformed into the corresponding acid products in good yields with high stereoselectivity.