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Copper‐Catalyzed Four‐Component Reaction for the Synthesis of N ‐Difluoroethyl Imides
Author(s) -
Gao Yu,
Peng ShanQing,
Liu DeYong,
Rui PeiXin,
Hu XiangGuo
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801334
Subject(s) - chemistry , catalysis , combinatorial chemistry , copper , surface modification , component (thermodynamics) , molecule , organic chemistry , physics , thermodynamics
A general and efficient method for the synthesis N ‐difluoroethyl imides has been developed. This copper‐catalyzed four‐component reaction proceeds via in‐situ generated difluorodiazomethane, which does not require prior formation and transferring. The reaction is scalable, tolerant toward a range of functional groups, and also suitable for the late‐stage functionalization of drugs and drug‐like molecules.