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Substituted ( E )‐2‐Methylene‐3,4‐cyclohexenones through Direct and Convenient Synthesis from Cyclohexenone‐MBH Alcohol in the Presence of DMAP
Author(s) -
Ren HongXia,
Song XiangJia,
Wu Lin,
Huang ZhiCheng,
Zou Ying,
Li Xia,
Chen XiaoWen,
Tian Fang,
Wang LiXin
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801301
Subject(s) - cyclohexenone , chemistry , alcohol , methylene , combinatorial chemistry , simple (philosophy) , organic chemistry , epistemology , philosophy
An unexpected and effective DMAP catalyzed one‐step construction of 3,4‐cyclohexenone skeleton from simple and easily available cyclohexenone‐MBH alcohol has been disclosed. A series of substituted (E)‐2‐methylene‐3,4‐cyclohexenones have been effectively prepared in excellent yields (up to 93 %) under convenient reaction conditions. Succesful scale‐up preparation and synthetic transformations have demonstrated the potentials of this new protocol.