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Synthesis of Phenyl Dithiocarbamates Starting from Sodium Dialkyldithiocarbamates and Aryl Boronic Acids: a Copper Catalyzed S ‐Arylation
Author(s) -
Gao MingYuan,
Xu Wan,
Zhang ShiBo,
Li YueSheng,
Dong ZhiBing
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801271
Subject(s) - chemistry , aryl , catalysis , copper , bromide , combinatorial chemistry , sodium , substrate (aquarium) , sodium bromide , organic chemistry , scope (computer science) , oceanography , alkyl , geology , computer science , programming language
A convenient and efficient protocol for the S ‐arylation of sodium dialkyldithiocarbamates was developed. With the catalysis of copper(I) bromide, sodium dialkyldithiocarbamates coupled with aryl boronic acids giving the C‐S coupling products smoothly in good to excellent yields. This protocol features easily available starting materials, easy performance, short reaction time, broad substrate scope and good yields, showing its potential synthetic value for the convenient preparation of some potentially biologically active compounds.