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1,2‐Diaza‐1,3‐diene‐Based Multicomponent Reactions in Sequential Protocols to Synthesize Arylamino‐5‐hydrazonothiophene‐3‐carboxylates
Author(s) -
Mari Giacomo,
De Crescentini Lucia,
Favi Gianfranco,
Santeusanio Stefania,
Mantellini Fabio
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801228
Subject(s) - chemistry , diene , combinatorial chemistry , computational chemistry , stereochemistry , organic chemistry , natural rubber
Two unprecedented approaches to amply functionalized 2‐arylamino‐5‐hydrazonothiophene‐3‐carboxylates were reported. The first one is a useful metal‐free sequential multicomponent synthesis of readily available β‐keto esters, isothiocyanates and in situ generated 4‐unsubstituted diazadienes. The second one is the basic treatment of 2,5‐dihydrothiophenes previously prepared by means of an analogous sequential multicomponent synthesis where 4‐substituted diazadienes were employed.