Au‐Catalyzed Addition of Nucleophiles to Chloroalkynes: A Regio‐ and Stereoselective Synthesis of ( Z )‐Alkenyl Chlorides | Zendy

Liu Congrong | Zendy; Xue Yunbo | Zendy; Ding Lianghui | Zendy; Zhang Haiyun | Zendy; Yang Fulai | Zendy

Premium

Au‐Catalyzed Addition of Nucleophiles to Chloroalkynes: A Regio‐ and Stereoselective Synthesis of ( Z )‐Alkenyl Chlorides

Author(s) -

Liu Congrong,

Xue Yunbo,

Ding Lianghui,

Zhang Haiyun,

Yang Fulai

Publication year - 2018

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201801222

Subject(s) - stereoselectivity , chemistry , nucleophile , catalysis , regioselectivity , nucleophilic addition , organic chemistry , medicinal chemistry , stereochemistry

An unprecedented protocol has been developed for the regio‐ and stereoselective synthesis of ( Z )‐alkenyl chlorides via the gold‐catalyzed addition of nucleophiles to chloroalkynes. In the presence of 1 mol‐% BrettPhosAuCl, a broad range of nucleophiles smoothly react with aromatic, vinylic, or aliphatic chloroalkynes to afford various functionalized ( Z )‐alkenyl chlorides with high to excellent yields and extremely high stereoselectivity.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research