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Copper‐Catalyzed (Di)Arylmethylation of Phosphorylamides Under Oxidative Conditions
Author(s) -
Zhao Zijian,
Liu Xiaobo,
Hou Anguo,
Lian Yan
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801194
Subject(s) - chemistry , catalysis , oxidative phosphorylation , copper , peroxide , iodide , organic chemistry , combinatorial chemistry , biochemistry
A compatible and practical (di)arylmethylation of phosphorylamides was successfully accessed in the presence of copper iodide as the catalyst, azodiisobutyronitrile as the radical initiator, and di‐ tert ‐butyl peroxide as the oxidant. Both methylarenes and diaryl methanes were compatible under the oxidative conditions, enjoying broad functional groups tolerance (51 examples) and good efficiency (up to 90 % yields).