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The Diverse One‐Pot Reactions of 2‐Quinolylzincates: Homologation, Electrophilic Trapping, Hydroxylation, and Arylation Reactions
Author(s) -
Jeong Hye Jin,
Chae Suyeon,
Jeong Keunhong,
Namgoong Sung Keon
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801192
Subject(s) - chemistry , regioselectivity , metalation , electrophile , hydroxylation , quinoline , electrophilic substitution , combinatorial chemistry , reactive intermediate , organic chemistry , catalysis , enzyme
2‐Quinolylzincates were efficiently produced from the regioselective metalation reactions of quinoline with various organozincates as key intermediates. The four different types of title reactions of these intermediates under the presented reaction conditions allowed for the facile formation of the corresponding C‐2 functionalized quinolines, which are not successfully accessed through typical zincation methods.