Convenient and Efficient Diastereoselective Preparation of Functionalized  Z ‐Alkenyl Sulfides | Zendy

Doroszuk Justyna | Zendy; Musiejuk Mateusz | Zendy; Ponikiewski Łukasz | Zendy; Witt Dariusz | Zendy

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Convenient and Efficient Diastereoselective Preparation of Functionalized Z ‐Alkenyl Sulfides

Author(s) -

Doroszuk Justyna,

Musiejuk Mateusz,

Ponikiewski Łukasz,

Witt Dariusz

Publication year - 2018

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201801181

Subject(s) - chemistry , stereoselectivity , lithium (medication) , organic chemistry , copper , lithium chloride , chloride , reaction conditions , combinatorial chemistry , medicinal chemistry , catalysis , medicine , endocrinology

We have developed an efficient and convenient regio‐ and stereoselective reduction of the alkynyl sulfides with pinacolborane in the presence of copper(I) chloride to produce ( Z )‐alkenyl sulfides in good and very good yields. The functionalized alkynyl sulfides are readily available based on the reaction of lithium acetylides with thiotosylates under mild conditions.

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