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Synthesis of Chromone‐Containing Allylmorpholines through a Morita–Baylis–Hillman‐Type Reaction
Author(s) -
Chernov Nikita M.,
Shutov Roman V.,
Barygin Oleg I.,
Dron Mikhail Y.,
Starova Galina L.,
Kuz'mich Nikolay N.,
Yakovlev Igor P.
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801159
Subject(s) - chemistry , chromone , baylis–hillman reaction , stereochemistry , morita therapy , functional group , organic chemistry , catalysis , psychology , polymer , psychoanalysis
The first example of an unusual addition of chromone‐substituted acrylic acid to enamines is described. The process shows high versatility concerning both enamines and chromones. The reaction is catalyzed by tertiary amines and is highly likely of Morita–Baylis–Hillman‐type. The described compounds show combined moderate inhibitory action on BChE and antagonism towards NMDA receptors which makes them a perspective group for the development of anti‐Alzheimer drugs.