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Chemoselective Alkylation of Aminoacetophenones with Alcohols by Using a Palladacycle‐Phosphine Catalyst
Author(s) -
Mamidala Ramesh,
Subramani M. Siva,
Samser Shaikh,
Biswal Priyabrata,
Venkatasubbaiah Krishnan
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801155
Subject(s) - alkylation , chemistry , phosphine , catalysis , organic chemistry , combinatorial chemistry
The development of efficient and environmentally benign palladacycle‐phosphine catalyzed process to enable the formation of chemoselective C‐alkylated or N‐alkylated aminoacetophenones with alcohols is described. This methodology proved to be tunable by variation of the base and the temperature, which allows for the isolation of structurally diverse C‐alkylated and N‐alkylated aminoacetophenones. Moreover, this methodology has been applied to the synthesis of biologically and industrially important donepezil.