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An Efficient Two‐Step Preparation of α‐, β‐, γ‐ or δ‐Amino Acids from 2‐Pyrazinones, 2‐Hydroxypyrimidines or 2‐Pyridones Respectively
Author(s) -
Zacharie Boulos,
Abbott Shaun D.,
Baigent Christopher B.,
Doyle Christopher,
Yalagala Ravi Shekar
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801134
Subject(s) - chemistry , amino acid , combinatorial chemistry , organic chemistry , biochemistry
A practical and efficient two‐step procedure is reported for the preparation of a variety of α‐, β‐, γ‐ and δ‐amino acids from 2‐pyridone, 2‐pyrazinone or 2‐hydroxypyrimidine and derivatives. The procedure is amenable to scale‐up and in most cases no chromatographic purification of the product is required. This approach is useful, especially in the synthesis of amino acids or deuterated amino acids that are not obtained by other methods.