Premium
Copper(II)‐Promoted Cascade Synthesis of 2‐Aminobenzothiazoles Starting from 2‐Iodoanilines and Sodium Dithiocarbamates
Author(s) -
Zhu Hui,
Zhang ShiBo,
Liu Xing,
Cheng Yu,
Peng HanYing,
Dong ZhiBing
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801122
Subject(s) - chemistry , cascade , copper , combinatorial chemistry , sodium , reaction conditions , ligand (biochemistry) , organic chemistry , catalysis , receptor , biochemistry , chromatography
A facile and efficient formation of 2‐aminobenzothiazoles by a copper(II)‐promoted one‐pot cascade process was developed. The desired 2‐aminobenzothiazoles were synthesized in good to excellent yields (up to 97 %) in the presence of Cu(OAc) 2 and K 2 CO 3 , a variety of functional groups on 2‐iodoanilines could be tolerated. The method features ligand‐free and mild reaction conditions and good yields, illustrating its practical synthetic value in some potentially biologically active compounds.