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CpTiCl 2 , an Improved Titanocene(III) Catalyst in Organic Synthesis
Author(s) -
RoldanMolina Esther,
Padial Natalia M.,
Lezama Luis,
Oltra J. Enrique
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801120
Subject(s) - chemistry , catalysis , enantioselective synthesis , denticity , electron paramagnetic resonance , ligand (biochemistry) , organic synthesis , organometallic chemistry , organic chemistry , combinatorial chemistry , metal , biochemistry , physics , receptor , nuclear magnetic resonance
Preparation, EPR analysis, and advantages in green organic chemistry of CpTiCl 2 , an improved single‐electron transfer catalyst, are reported. Under mild conditions, this organometallic complex provides excellent yields of homoallylic and homopropargylic alcohols in Barbier‐type allylation and propargylation reactions. Moreover, in the presence of a bidentate BOX ligand, Barbier‐type cyclization reactions catalyzed by CpTiCl 2 can be carried out in an enantioselective manner.