Premium
Front Cover: Laccase‐Based Oxidative Catalytic Systems for the Aerobic Aromatization of Tetrahydroquinazolines and Related N‐Heterocyclic Compounds under Mild Conditions (Eur. J. Org. Chem. 30/2018)
Author(s) -
Saadati Shaghayegh,
Ghorashi Nadya,
Rostami Amin,
Kobarfard Farzad
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801099
Subject(s) - chemistry , aromatization , dehydrogenation , laccase , catalysis , intramolecular force , substrate (aquarium) , oxidative phosphorylation , redox , oxygen , molecular oxygen , combinatorial chemistry , organic chemistry , photochemistry , enzyme , biochemistry , oceanography , geology
The Front Cover shows that the biomimetic aerobic oxidative dehydrogenation of nitrogen heterocycles proceeds via intramolecular cooperation between a laccase, as a multi‐copper oxidase, and 3,5‐di‐tert‐butylcatechol (DTBC) or 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO), as an organic co‐catalyst, by means of a low‐activation‐energy process in a green solvent. Molecular oxygen cannot directly oxidize nitrogen heterocycles under mild conditions, therefore, appropriate redox compounds (similar to puzzle pieces) must be employed as a bridge (mediator) between molecular oxygen and the substrate. More information can be found in the Communication by A. Rostami, F. Kobarfard et al.