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A para ‐C–H Functionalization of Aniline Derivatives via In situ Generated Bulky Hypervalent Iodinium Reagents
Author(s) -
Tian Chao,
Yao Xu,
Ji Weizhe,
Wang Qian,
An Guanghui,
Li Guangming
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801058
Subject(s) - chemistry , aniline , reagent , hypervalent molecule , surface modification , combinatorial chemistry , in situ , transition metal , recrystallization (geology) , organic chemistry , catalysis , paleontology , biology
A practical para ‐C‐H functionalization of aniline derivatives has been developed using an in situ generated bulky hypervalent iodinium reagent. Para ‐iodo, bromo, chloro, nitro, trifluormethyl aniline derivatives can be obtained efficiently, in many cases in 10 min in a transition metal‐free manner. Medicinal chemicals or intermediates can be purified without column chromatography or recrystallization, which significantly reduces the waste and simplifies the work‐up process.