Cover Feature: Methods for the Synthesis of α,α‐Difluoroketones (Eur. J. Org. Chem. 27‐28/2018)

The Cover Feature shows a α,α‐difluoroketone, drawn in a style as if it were on a chalkboard to emphasize the tutorial nature of this Microreview. Some of the key strategies for the synthesis of α,α‐difluoroketones are depicted. Moving clockwise from top left these include: 1) the direct difluorination of ketones via enolate equivalents; 2) nucleophilic displacements of difluorinated esters; 3) alkylation and coupling reactions of difluoro‐enolate equivalents; 4) radical and coupling reactions of difluoro‐haloketones. More information can be found in the Microreview by G. Pattison .