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Cover Feature: Methods for the Synthesis of α,α‐Difluoroketones (Eur. J. Org. Chem. 27‐28/2018)
Author(s) -
Pattison Graham
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801029
Subject(s) - chemistry , cover (algebra) , nucleophile , alkylation , feature (linguistics) , coupling (piping) , computational chemistry , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , mechanical engineering , linguistics , philosophy , engineering
The Cover Feature shows a α,α‐difluoroketone, drawn in a style as if it were on a chalkboard to emphasize the tutorial nature of this Microreview. Some of the key strategies for the synthesis of α,α‐difluoroketones are depicted. Moving clockwise from top left these include: 1) the direct difluorination of ketones via enolate equivalents; 2) nucleophilic displacements of difluorinated esters; 3) alkylation and coupling reactions of difluoro‐enolate equivalents; 4) radical and coupling reactions of difluoro‐haloketones. More information can be found in the Microreview by G. Pattison .