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Insights into the Structure and Function of a Chiral Conjugate‐Base‐Stabilized Brønsted Acid Catalyst
Author(s) -
Odagi Minami,
Araki Hiroshi,
Min Chang,
Yamamoto Eri,
Emge Thomas J.,
Yamanaka Masahiro,
Seidel Daniel
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801024
Subject(s) - chemistry , brønsted–lowry acid–base theory , conjugate , catalysis , base (topology) , function (biology) , organic chemistry , stereochemistry , combinatorial chemistry , mathematical analysis , mathematics , evolutionary biology , biology
A combined experimental and computational study reveals key catalyst‐substrate interactions and the main factors controlling stereoselectivity in an asymmetric Pictet–Spengler reaction facilitated by a carboxylic‐acid‐thiourea catalyst.