Premium
Sterically Congested Ester Formation from α‐Substituted Malononitrile and Alcohol by an Oxidative Method Using Molecular Oxygen
Author(s) -
Hayashi Yujiro,
Li Jing,
Asano Hirotaka,
Sakamoto Daisuke
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800984
Subject(s) - malononitrile , chemistry , alcohol , steric effects , thiol , thio , oxygen , organic chemistry , molecular oxygen , oxidative phosphorylation , catalysis , biochemistry
A metal‐free oxidative esterification or thio‐esterification of readily available substituted malononitrile and alcohol or thiol has been developed by simply mixing α‐substituted malononitrile and alcohol or thiol in the presence of base under a molecular oxygen atmosphere. Sterically hindered ester or thioester can be prepared efficiently.