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Metal‐Free Chlorothiolation of Alkenes Using HCl and Sulfoxides
Author(s) -
Ebule Rene,
Hammond Gerald B.,
Xu Bo
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800973
Subject(s) - chemistry , reagent , combinatorial chemistry , alkene , organic chemistry , sulfoxide , metal , catalysis
We report a novel method for the chlorothiolation of alkenes using HCl and sulfoxides to achieve the 1,2‐difunctionalization of unactivated alkenes. The combination of our new HCl reagent (HCl/DMPU) with sulfoxides forms a unique chlorothiolation system. Both terminal and internal alkenes are suitable substrates. This method works at gram scale and is applicable in further synthetic elaborations.