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Front Cover: Developing Cyclic Peptide Heteroatom Interchange: Synthesis and DFT Modelling of a HI‐Ascidiacyclamide Isomer (Eur. J. Org. Chem. 25/2018)
Author(s) -
Xie Sida,
Savchenko Andrei I.,
Krenske Elizabeth H.,
Grange Rebecca L.,
Gahan Lawrence R.,
Williams Craig M.
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800902
Subject(s) - front cover , heteroatom , chemistry , great barrier reef , peptide , sulfur , cover (algebra) , supramolecular chemistry , stereochemistry , thiazole , ring (chemistry) , molecule , organic chemistry , oceanography , reef , biochemistry , geology , mechanical engineering , engineering
The Front Cover shows the ascidian Lissoclinum Patella in the Great Barrier Reef, Queensland, Australia. The thiazole‐containing cyclic peptide ascidiacyclamide was isolated from L. Patella and in this Communication the concept of heteroatom interchange is applied to ascidiacyclamide. Transposing the nitrogen and sulfur atoms of both thiazoles significantly impacts the 3D structure and metal‐binding properties of the peptide. Prof. Marcel Jaspars (Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen) is kindly acknowledged for the L. Patella image. More information can be found in the Communication by L. R. Gahan, C. M. Williams et al.