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An Efficient Chan–Lam S ‐Arylation of Arylthioureas with Arylboronic Acids
Author(s) -
Liu Xing,
Zhang ShiBo,
Zhu Hui,
Cheng Yu,
Peng HanYing,
Dong ZhiBing
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800892
Subject(s) - chemistry , thiourea , aryl , reagent , combinatorial chemistry , catalysis , ligand (biochemistry) , reaction conditions , organic chemistry , functional group , medicinal chemistry , receptor , biochemistry , alkyl , polymer
A convenient and efficient protocol has been developed for the preparation of aryl‐isothioureas based on the Chan–Lam C–S coupling reaction. The desired aryl‐isothioureas were synthesized in good yields (up to 95 %) in the presence of Cu(OAc) 2 · H 2 O as catalyst and bipyridine as ligand. A variety of functional groups on the aryl‐thiourea and arylboronic acid reagents are tolerated. The method features mild reaction conditions and good yields, thereby illustrating its practical synthetic value in organic synthesis.