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Synthesis of Euchrestifoline Using Iron‐ and Palladium‐Catalyzed C–H Bond Activations
Author(s) -
Puls Florian,
Kataeva Olga,
Knölker HansJoachim
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800872
Subject(s) - chemistry , palladium , catalysis , amination , natural product , wacker process , derivative (finance) , combinatorial chemistry , organic chemistry , medicinal chemistry , financial economics , economics
We describe a short and efficient synthetic route to euchrestifoline. Key steps of our approach are the iron(III)‐catalyzed Wacker‐type oxidation of a chromene derivative with hexadecafluorophthalocyanine‐iron (FePcF 16 ) as catalyst, a palladium(0)‐catalyzed Buchwald–Hartwig amination, and the final palladium(II)‐catalyzed oxidative cyclization of the resulting diarylamine to the natural product.