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Recent Developments and Synthetic Applications of Nucleophilic Zirconocene Complexes from Schwartz's Reagent
Author(s) -
Pinheiro Danielle L. J.,
de Castro Pedro P.,
Amarante Giovanni W.
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800852
Subject(s) - chemistry , enantioselective synthesis , reagent , nucleophile , organic synthesis , context (archaeology) , zirconium , combinatorial chemistry , organic chemistry , metallocene , ring (chemistry) , chemical synthesis , coupling reaction , catalysis , paleontology , biochemistry , polymer , in vitro , polymerization , biology
Organozirconium chemistry has been widely employed in organic synthesis since its discovery in the last century. In this context, Schwartz's reagent stands out as a powerful tool that has been applied in several chemical transformations. This chemistry has attracted considerable attention due to its versatility, allowing chemoselective C–C, C–N, and C–X bond formation, as well as hydrozirconation. The reagent is in fact a zirconium‐containing metallocene, which is compatible with the presence of various metals in cross‐coupling reactions. Enantioselective transformations of organozirconium are described here, which have recently found wide applications in total synthesis. Furthermore, aspects covering ring‐closure reactions, affording complex stereoenriched cycles and heterocycles, such as substituted cyclopropanes and pyrrolidines, are hereby disclosed.