Premium
Iron‐Catalyzed Coupling of Propargyl Bromides and Alkyl Grignard Reagents
Author(s) -
DomingoLegarda Pablo,
SolerYanes Rita,
QuirósLópez M. Teresa,
Buñuel Elena,
Cárdenas Diego J.
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800849
Subject(s) - propargyl , chemistry , allene , reagent , regioselectivity , alkyl , halide , catalysis , coupling reaction , organic chemistry , coupling (piping) , medicinal chemistry , combinatorial chemistry , mechanical engineering , engineering
An iron‐catalyzed Kumada‐type cross‐coupling reaction of propargyl halides with alkylmagnesium reagents is described. The reaction is fast, takes place in smooth conditions, tolerates several functional groups that would be able to react with the Grignard reagent, and may afford either allene or propargyl coupling derivatives. Factors involved in the observed regioselectivity have been studied.