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Cover Feature: Synthesis of Bi‐ and Polyfunctional Isoxazoles from Amino Acid Derived Halogenoximes and Active Methylene Nitriles (Eur. J. Org. Chem. 22/2018)
Author(s) -
Chalyk Bohdan A.,
Hrebeniuk Kateryna V.,
Gavrilenko Konstantin S.,
Shablykin Oleh V.,
Yanshyna Oksana O.,
Bash Daniil,
Mykhailiuk Pavel K.,
Liashuk Oleksandr S.,
Grygorenko Oleksandr O.
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800818
Subject(s) - isoxazole , chemistry , ring (chemistry) , methylene , amino acid , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , biochemistry
The Cover Feature shows the retrosynthetic disconnection of 5‐amino‐3‐(piperidin‐4‐yl)isoxazole‐4‐carbonitrile, a representative of functionalized 5‐aminoisoxazoles, which is depicted schematically in “chemical space”. This compound, and other 5‐aminoisoxazoles bearing one or several additional functional groups, can be prepared by using the reaction of amino acid derived halogenoximes (to provide the CNO fragment of the isoxazole ring, shown in the light‐blue part of the picture) and active methylene nitriles (to provide the CC fragment of the isoxazole ring, as well as the amino function; shown in the dark‐blue part). More information can be found in the Full Paper by O. O. Grygorenko et al.