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Stereocontrolled Formal Synthesis of Platencin
Author(s) -
Hsu DayShin,
Hwang TaiYu
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800806
Subject(s) - chemistry , formal synthesis , yield (engineering) , aldol reaction , aldol condensation , derivative (finance) , total synthesis , stereoselectivity , enantioselective synthesis , intermolecular force , stereochemistry , combinatorial chemistry , organic chemistry , molecule , catalysis , materials science , economics , financial economics , metallurgy
A stereocontrolled formal synthesis of platencin was accomplished in 11 steps from a bromophenol derivative, with an overall yield of 13 %. The intermolecular Diels–Alder reaction of masked o ‐benzoquinone and an aldol condensation were the key steps in the construction of the tricyclic core of platencin.