Premium
Efficient Synthesis of Multifunctional Chelating Agents Based on Tetraazacycloalkanes
Author(s) -
Sok Nicolas,
Bernhard Claire,
Désogère Pauline,
Goze Christine,
Rousselin Yoann,
Boschetti Frédéric,
Baglin Isabelle,
Denat Franck
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800801
Subject(s) - chemistry , combinatorial chemistry , amine gas treating , chelation , functional group , primary (astronomy) , nanotechnology , organic chemistry , polymer , physics , astronomy , materials science
An efficient route has been developed for the synthesis of multifunctional tetraazacycloalkanes (in particular 1,4,7,10‐tetraazacyclotridecane) incorporating an aminomethyl pendant arm on the carbon skeleton. Starting from the appropriate C‐functionalized bisaminal‐protected intermediate, the target macrocycles were easily obtained by means of a step‐by‐step introduction of the desired functional groups onto the free primary amine group, followed by deprotection of the bisaminal intermediates. This straightforward and versatile synthetic approach paves the way for the design of a new family of multifunctional chelators.