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Synthesis of trans ‐β‐Elemene
Author(s) -
Benito Iglesias D.,
Herrero Teijón P.,
Rubio González Rosa,
FernándezMateos A.
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800800
Subject(s) - chemistry , stereoselectivity , elemene , combinatorial chemistry , stereochemistry , chloride , organic chemistry , catalysis , biochemistry , apoptosis
Highly efficient syntheses of the anti‐cancer agent trans ‐β‐elemene have been achieved by using the readily available (±)‐limonene as starting material. The syntheses were achieved in only nine to eleven steps with good overall yields. The key step in these reaction sequences is a stereoselective radical cyclization, induced by titanocene chloride.