Premium
Diversity‐Oriented Approach to Spirorhodanines via a [2+2+2] Cyclotrimerization
Author(s) -
Kotha Sambasivarao,
Sreevani Gaddamedi
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800775
Subject(s) - chemistry , propargyl , halide , sequence (biology) , combinatorial chemistry , diversity (politics) , xylylene , coupling (piping) , stereochemistry , polymer chemistry , organic chemistry , catalysis , mechanical engineering , biochemistry , sociology , anthropology , engineering
Spirocyclic compounds have been increasingly utilized in drug discovery due to their inherent three‐dimensional structural complexity. Here, we report a diversity oriented approach to spirorhodanines via a [2+2+2] cyclotrimerization reaction with propargyl halides as co‐partners. In another sequence, we employed o ‐xylylene dibromide as a coupling partner to assemble spirorhodanines.