Diversity‐Oriented Approach to Spirorhodanines via a [2+2+2] Cyclotrimerization | Zendy

Kotha Sambasivarao | Zendy; Sreevani Gaddamedi | Zendy

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Diversity‐Oriented Approach to Spirorhodanines via a [2+2+2] Cyclotrimerization

Author(s) -

Kotha Sambasivarao,

Sreevani Gaddamedi

Publication year - 2018

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201800775

Subject(s) - chemistry , propargyl , halide , sequence (biology) , combinatorial chemistry , diversity (politics) , xylylene , coupling (piping) , stereochemistry , polymer chemistry , organic chemistry , catalysis , mechanical engineering , biochemistry , sociology , anthropology , engineering

Spirocyclic compounds have been increasingly utilized in drug discovery due to their inherent three‐dimensional structural complexity. Here, we report a diversity oriented approach to spirorhodanines via a [2+2+2] cyclotrimerization reaction with propargyl halides as co‐partners. In another sequence, we employed o ‐xylylene dibromide as a coupling partner to assemble spirorhodanines.

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