A Convenient Synthesis of 1,2‐Disubstituted‐ cis ‐3,4‐Dihydroxypyrrolidines via an Ugi‐Four‐Component‐Reaction/Cycloisomerization/Dihydroxylation Protocol | Zendy

FloresConstante Gemma | Zendy; SánchezChávez Anahí C. | Zendy; PolindaraGarcía Luis A. | Zendy

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A Convenient Synthesis of 1,2‐Disubstituted‐ cis ‐3,4‐Dihydroxypyrrolidines via an Ugi‐Four‐Component‐Reaction/Cycloisomerization/Dihydroxylation Protocol

Author(s) -

FloresConstante Gemma,

SánchezChávez Anahí C.,

PolindaraGarcía Luis A.

Publication year - 2018

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201800756

Subject(s) - cycloisomerization , chemistry , dihydroxylation , adduct , ugi reaction , component (thermodynamics) , stereochemistry , combinatorial chemistry , organic chemistry , isocyanide , enantioselective synthesis , catalysis , physics , thermodynamics

Dihydroxypyrrolidines constitute an important group of biologically active molecules that are found in nature. In this paper, we report the development of a selective method for the synthesis of 1,2‐disubstituted‐ cis ‐3,4‐dihydroxypyrrolidines from Ugi four‐component‐reaction/propargylamine adducts through a 5‐ endo ‐ dig cycloisomerization and subsequent cis ‐dihydroxylation process.

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