Synthesis of 1,1‐Disubstituted  N ‐Acyl Tetrahydroisoquinolines from Enamides by Cascade Radical Addition and Cyclization | Zendy

Yu Hui | Zendy; Xuan Pengfei | Zendy; Jiao Mingdong | Zendy; Lin Jingbo | Zendy

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Synthesis of 1,1‐Disubstituted N ‐Acyl Tetrahydroisoquinolines from Enamides by Cascade Radical Addition and Cyclization

Author(s) -

Yu Hui,

Xuan Pengfei,

Jiao Mingdong,

Lin Jingbo

Publication year - 2018

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201800748

Subject(s) - chemistry , cascade , radical cyclization , atom economy , cascade reaction , copper , stereochemistry , catalysis , combinatorial chemistry , medicinal chemistry , organic chemistry , chromatography

Copper(I)‐catalyzed radical 1,2‐benzylarylation of N ‐phenethylenamides was developed and 1,1‐disubstituted N ‐acyl tetrahydroisoquinolines were obtained in moderate to good yields. In this process, two new C–C bonds were formed in one‐step fashion with high atom economy. A possible reaction pathway for the formation of the products is also discussed.

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