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Synthesis of 1,1‐Disubstituted N ‐Acyl Tetrahydroisoquinolines from Enamides by Cascade Radical Addition and Cyclization
Author(s) -
Yu Hui,
Xuan Pengfei,
Jiao Mingdong,
Lin Jingbo
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800748
Subject(s) - chemistry , cascade , radical cyclization , atom economy , cascade reaction , copper , stereochemistry , catalysis , combinatorial chemistry , medicinal chemistry , organic chemistry , chromatography
Copper(I)‐catalyzed radical 1,2‐benzylarylation of N ‐phenethylenamides was developed and 1,1‐disubstituted N ‐acyl tetrahydroisoquinolines were obtained in moderate to good yields. In this process, two new C–C bonds were formed in one‐step fashion with high atom economy. A possible reaction pathway for the formation of the products is also discussed.