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Cover Feature: N ‐Acyl‐Glutarimides: Privileged Scaffolds in Amide N–C Bond Cross‐Coupling (Eur. J. Org. Chem. 20‐21/2018)
Author(s) -
Meng Guangrong,
Szostak Michal
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800741
Subject(s) - chemistry , amide , regioselectivity , peptide bond , bond cleavage , reactivity (psychology) , catalysis , cleavage (geology) , stereochemistry , combinatorial chemistry , organic chemistry , enzyme , engineering , medicine , alternative medicine , geotechnical engineering , pathology , fracture (geology)
The Cover Feature shows the key property of N‐acyl‐glutarimides that enabled the development of a broad range of powerful transformations by chemo‐ and regioselective N–C amide bond cleavage. Since the initial reports in 2015, these amides have been demonstrated to be by far the most reactive amide derivatives in the biologically relevant manifold of N–C activation/cross‐coupling, thus stimulating the development of more than ten previously unknown catalytic modes of reactivity of the amide bond by Pd, Ni, and Rh catalysis. More information can be found in the Microreview by G. Meng and M. Szostak .