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Cover Feature: A Ring‐Distortion Strategy from Marine Natural Product Ilimaquinone Leads to Quorum Sensing Modulators (Eur. J. Org. Chem. 20‐21/2018)
Author(s) -
Evanno Laurent,
Lachkar David,
Lamali Assia,
Boufridi Asmaa,
SéonMéniel Blandine,
Tintillier Florent,
Saulnier Denis,
Denis Stéphanie,
GentaJouve Grégory,
Jullian JeanChristophe,
Leblanc Karine,
Beniddir Mehdi A.,
Petek Sylvain,
Debitus Cécile,
Poupon Erwan
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800740
Subject(s) - natural product , chemistry , cover (algebra) , quorum sensing , ring (chemistry) , moiety , feature (linguistics) , distortion (music) , stereochemistry , combinatorial chemistry , nanotechnology , organic chemistry , computer science , biochemistry , engineering , telecommunications , philosophy , virulence , gene , mechanical engineering , amplifier , linguistics , materials science , bandwidth (computing)
The Cover Feature shows a ring‐distortion strategy applied to the marine natural product ilimaquinone. A chemically diverse library of molecules was synthesised that included rearrangements of the sesquiterpene moiety and original reorganisations of the quinone ring. Compounds were evaluated as quorum sensing inhibitors of Vibrio Harveyi , an economically important pathogen in French Polynesia. This work is depicted in a festive theme for the special issue celebrating the 20th anniversary of the journal. More information can be found in the Full Paper by L. Evanno, E. Poupon et al.