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Convenient Synthesis of Quinoline‐4‐carboxylate Derivatives through the Bi(OTf) 3 ‐Catalyzed Domino Cyclization/Esterification Reaction of Isatins with Enaminones in Alcohols
Author(s) -
Zhou Pan,
Hu Biao,
Wang Yanqin,
Zhang Qiaohe,
Li Xiang,
Yan Shengjiao,
Yu Fuchao
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800734
Subject(s) - chemistry , quinoline , catalysis , cascade reaction , domino , substrate (aquarium) , carboxylate , combinatorial chemistry , organic chemistry , ring (chemistry) , primary (astronomy) , oceanography , geology , physics , astronomy
An efficient Bi(OTf) 3 ‐catalyzed method for the synthesis of quinoline‐4‐carboxylates through a domino cyclization/esterification reaction of isatins with enaminones in alcohols is reported. The salient features are the formation of the quinoline ring and an acyl–oxygen bond in one step, the use of readily available starting materials, and the wide substrate scope.