Palladium‐Catalyzed Reaction of MBH Acetates and Terminal Alkynes: Cascade Synthesis of Phenanthridine and 6‐Arylethynylphenanthridine | Zendy

Gupta Tanu | Zendy; Singh Jay Bahadur | Zendy; Singh Rashmi | Zendy; Singh Radhey M. | Zendy

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Palladium‐Catalyzed Reaction of MBH Acetates and Terminal Alkynes: Cascade Synthesis of Phenanthridine and 6‐Arylethynylphenanthridine

Author(s) -

Gupta Tanu,

Singh Jay Bahadur,

Singh Rashmi,

Singh Radhey M.

Publication year - 2018

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201800725

Subject(s) - chemistry , phenanthridine , palladium , regioselectivity , catalysis , cascade , cascade reaction , combinatorial chemistry , medicinal chemistry , organic chemistry , chromatography

We have described the palladium‐catalyzed regioselective cascade synthesis of phenanthridines and 6‐arylethynylphenanthridines in good to excellent yields from a reaction between Morita–Baylis–Hillman (MBH) acetates and terminal alkynes. These cascade reactions are temperature controlled and favor the formation of phenanthridines when conducted at 50 °C and of 6‐arylethynylphenanthridines when performed at 80 °C.

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