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An Improved Synthesis of the Antibiotic Dehydrophos
Author(s) -
JiménezAndreu M. Mercedes,
Sayago Francisco J.,
Cativiela Carlos
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800689
Subject(s) - chemistry , phosphonate , moiety , residue (chemistry) , tripeptide , hydrolysis , stereochemistry , protecting group , formaldehyde , combinatorial chemistry , total synthesis , metathesis , peptide , organic chemistry , biochemistry , alkyl , polymerization , polymer
Within this work an efficient procedure for the synthesis of the vinyl phosphonate tripeptide dehydrophos is described. This procedure constitutes a significant improvement over previously described strategies, since critical transformations in the synthesis of dehydrophos were carried out in only two synthetic steps, with higher yields and under smooth conditions. Thus, the dehydrophosphoalanine residue was generated by means of the Horner–Wadsworth–Emmons reaction of formaldehyde with a peptide bearing an aminomethylbis(phosphonate) moiety, whereas deprotection of the N ‐terminal position of the thus‐obtained dehydrophosphonopeptide and partial hydrolysis of the dimethyl phosphonate residue took place simultaneously. In addition, we confirmed that the chiral integrity of the leucine residue was preserved throughout these transformations.