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An Intramolecular C(sp 2 )–H Amidation Using N ‐Iodosuccinimide
Author(s) -
Alam Md Toufique,
Maiti Saikat,
Mal Prasenjit
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800688
Subject(s) - chemistry , intramolecular force , iodine , reagent , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry
An N ‐iodosuccinimide (NIS) mediated intramolecular dehydrogenative C(sp 2 )–H amidation is reported for easy and convenient access to 1,2‐disubstituted benzimidazoles. The nonprefunctionalized C(sp 2 )–H and N(sp 3 )–H bonds were directly coupled using NIS in trifluoroethanol, which proved to be mild alternative to strong oxidative iodine(III) reagents. The reaction worked at room temperature, under an air atmosphere, and in the absence of any base additive.