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Reintroducing Azidodifluoromethane: Synthesis, Stability and [3+2] Cycloadditions
Author(s) -
Voltrová Svatava,
Putovný Igor,
Matoušek Václav,
Klepetářová Blanka,
Beier Petr
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800650
Subject(s) - chemistry , azide , alkyne , ketone , yield (engineering) , ammonium chloride , cycloaddition , chloride , organic chemistry , combinatorial chemistry , catalysis , materials science , metallurgy
Azidodifluoromethane was prepared in 65 % yield from chlorodifluoromethane by a two‐step synthesis using tributyl(difluoromethyl)ammonium chloride as an intermediate. The resulting azide was used in Huisgen azide‐alkyne reactions and ketone [3+2] cycloadditions to access novel N ‐difluoromethyl‐1,2,3‐triazoles.