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Adenine Derivatives: Promising Candidates for Breast Cancer Treatment
Author(s) -
Figueiredo Pedro,
Costa Marta,
Pontes Olívia,
Baltazar Fátima,
Proença Fernanda
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800629
Subject(s) - chemistry , regioselectivity , mcf 7 , combinatorial chemistry , breast cancer , methylene , cancer , acetic acid , apoptosis , cancer research , stereochemistry , biochemistry , organic chemistry , human breast , medicine , biology , catalysis
The cascade reaction of N ‐aryl‐5‐{[(dimethylamino)methylene]amino}‐4‐cyanoimidazoles with primary aromatic amines, under reflux in acetic acid, proved to be a general and efficient method for the regioselective synthesis of 6‐arylaminopurines. A selection of these compounds was tested in breast cancer cell models MCF‐7 and Hs578t and five compounds proved to be highly active and non‐toxic to the non‐neoplastic cell line MCF‐10A. Furthermore, the compounds demonstrated apoptosis‐inducing capacity in the cancer cells.