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An Approach to One‐Pot Regioselective Synthesis of Indenones through Palladium‐Catalyzed Annulation in Water
Author(s) -
Ramesh Karu,
Satyanarayana Gedu
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800591
Subject(s) - annulation , chemistry , regioselectivity , palladium , catalysis , combinatorial chemistry , natural product , solvent , organic chemistry
A one‐pot synthesis of indenones is presented. The process involves palladium‐catalyzed annulation of ortho ‐halobenzaldehydes with internal alkynes. Notably, it proceeded successfully in water as the sole, and green, solvent. Significantly, unlike in earlier reports, this protocol showed excellent regioselectivity with unsymmetrical alkylarylacetylenes. Further, the strategy was extended to a one‐pot synthesis of a neolignan natural product.