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One‐Pot Sequential Bromination and Fluorination to Access 3‐Fluoroimidazo[1,2‐ a ]pyridines from Arylketones
Author(s) -
Udavant Rohini N.,
Yadav Ashok R.,
Shinde Sandip S.
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800578
Subject(s) - halogenation , chemistry , selectfluor , tribromide , reagent , organic chemistry , sequence (biology) , condensation , combinatorial chemistry , biochemistry , physics , thermodynamics
3‐Fluoro‐2‐arylimidazo[1,2‐ a ]pyridines were selectively synthesised in one‐pot from acetophenones and 2‐aminopyridines under mild conditions. The sequence of reactions involved bromination, condensation, and late‐stage fluorination. Two halogenating reagents play key roles in the process. We found that tetrabutylammonium tribromide and Selectfluor TM gave excellent yields of the desired products in the one‐pot sequential reaction.