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Pd II ‐Catalyzed Purine‐Directed Ortho Nitration of 6‐Arylpurines by C(sp 2 )–H Activation: A Practical Approach to Synthesize 6‐(2‐Nitroaryl)‐Purine Derivatives
Author(s) -
Gou Quan,
Li Wenxi,
Zhao Qingsheng,
Xie Jia,
Luo Ping,
Cao Guang,
Chen Suiyun,
Qin Jun
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800567
Subject(s) - nitration , chemistry , chemoselectivity , purine , catalysis , combinatorial chemistry , purine metabolism , reaction conditions , functional group , medicinal chemistry , organic chemistry , enzyme , polymer
Herein we report a method for Pd II ‐catalyzed purine‐directed ortho nitration of 6‐arylpurines via C(sp 2 )–H activation by using t BuONO/O 2 as nitration agent. This procedure is highly efficient and produces a range of 6‐(2‐nitroaryl)‐purine derivatives with good chemoselectivity and functional‐group tolerance. The utility of the method is further illustrated in the synthesis of antibacterial agent.