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Sulfonyl Fluorides (SFs): More Than Click Reagents?
Author(s) -
Chinthakindi Praveen K.,
Arvidsson Per I.
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800464
Subject(s) - sulfonyl , chemistry , reagent , fluoride , organic chemistry , click chemistry , combinatorial chemistry , inorganic chemistry , alkyl
Sulfonyl fluoride (SF) containing substances are currently attracting enormous attention among practitioners of both chemical biology and synthetic organic chemistry. The groups of Jones and Liskamp have demonstrated the potential of sulfonyl fluorides as selective covalent inhibitors in studies related to drug discovery and chemical biology, respectively, in the last few years. The Sharpless group has extended the repertoire of “click‐reactions” to those involving sulfonyl fluorides, that is, sulfur–fluoride exchange (SuFEx), a development that quickly triggered the interest in this functional group in the community of synthetic organic chemists. In this microreview, we aim to give an account of the synthetic chemistry surrounding sulfonyl fluoride containing substances from a historical perspective to present day developments.