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Organocatalytic Asymmetric Decarboxylative Addition of β‐Ketoacids to Methyleneindolinones Derivatives
Author(s) -
Kumari Anita,
Kaur Jasneet,
Bhardwaj Vimal K.,
Chimni Swapandeep Singh
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800454
Subject(s) - squaramide , chemistry , enantioselective synthesis , oxindole , organocatalysis , enantiomeric excess , enantiomer , cinchonidine , organic chemistry , catalysis , combinatorial chemistry
The quinine squaramide‐catalyzed enantioselective decarboxylative addition reaction of various β‐keto acids with methyleneindolinones has been developed. Through this methodology, various oxindole derivatives were synthesized in good yields (up to 93 %) and excellent enantiomeric excess (up to 99 % ee ) and moderate diastereoselectivity (up to 66:34).