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Front Cover: Analogues of Abscisic Acid – Insights into their Activity in Vitro and in Vivo (Eur. J. Org. Chem. 12/2018)
Author(s) -
Frackenpohl Jens,
Grill Erwin,
Bojack Guido,
Baltz Rachel,
Busch Marco,
Dittgen Jan,
Franke Jana,
Freigang Jörg,
Gonzalez Susana,
Heinemann Ines,
Helmke Hendrik,
Hills Martin,
Hohmann Sabine,
KoskullDöring Pascal,
Kleemann Jochen,
Lange Gudrun,
Lehr Stefan,
Müller Thomas,
Peschel Elisabeth,
Poree Fabien,
Schmutzler Dirk,
Schulz Arno,
Willms Lothar,
Wunschel Christian
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800414
Subject(s) - abscisic acid , in vivo , chemistry , cyclohexanone , front cover , in vitro , click chemistry , canola , drought stress , stereochemistry , biochemistry , cover (algebra) , combinatorial chemistry , botany , microbiology and biotechnology , biology , food science , catalysis , mechanical engineering , gene , engineering
The Front Cover shows common iterative steps of modern agrochemical research in the foreground with ears of wheat plants close to being harvested in the background. Inspired by nature, that is, by plant hormone abscisic acid (ABA), novel lead structures targeting drought stress in crops such as wheat or canola have been identified. In vivo SAR studies based on greenhouse trials and chemical optimization were supported by systems biology, in vitro analyses, and X‐ray crystallography. It could thus be explored how modification of the key structural features of ABA influences receptor affinity and in vivo efficacy. As a result, cyano‐cyclopropyl groups proved to be suitable replacements for the cyclohexanone headgroup motif. More information can be found in the full papers by J. Frackenpohl, E. Grill et al. ( ejoc.201701687 and ejoc.201701769 )