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Branched‐Selective Decarboxylative Heck Reaction with Electronically Unbiased Olefins
Author(s) -
Shen Jianchen,
Xu Biping,
Zhang Min,
Su Weiping
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800330
Subject(s) - chemistry , regioselectivity , heck reaction , alkyl , yield (engineering) , organic chemistry , reagent , decarboxylation , aryl , combinatorial chemistry , catalysis , materials science , metallurgy
We describe the Pd II ‐catalyzed decarboxylative Heck reaction of aromatic carboxylic acids with an array of electronically unbiased olefins, which allows regioselective formation of less common branched products in good yield. This protocol enables the use of inexpensive, stable, and readily available aromatic carboxylic acids as aryl reagents, thus providing an attractive method for the synthesis of useful α‐alkyl vinylarenes.