Premium
Diels–Alder Reaction in the Synthesis of Fluorinated (Hetero)Aromatic Compounds
Author(s) -
Kondratov Ivan S.,
Tolmachova Nataliya A.,
Haufe Günter
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800327
Subject(s) - aromatization , chemistry , cycloaddition , diels–alder reaction , fluorine , organic chemistry , molecule , aromaticity , combinatorial chemistry , catalysis
Numerous fluorinated (hetero)aromatic compounds have been synthesized by using the Diels–Alder reaction of fluorinated dienes/dienophiles with subsequent aromatization of the initially formed [4+2]‐cycloaddition products by various methods. This microreview presents diverse applications of the approach starting from the first examples in the 1960s up to recent advanced applications to illustrate the high potential of the method for the introduction of fluorine/polyfluoroalkyl substituents into (hetero)aromatic molecules.