Iron(III) Porphyrin Catalyzed Olefination of Aldehydes with 2,2,2‐Trifluorodiazoethane (CF 3 CHN 2 ) | Zendy

Lu Yang | Zendy; Huang Chuyu | Zendy; Liu Chao | Zendy; Guo Yong | Zendy; Chen QingYun | Zendy

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Iron(III) Porphyrin Catalyzed Olefination of Aldehydes with 2,2,2‐Trifluorodiazoethane (CF 3 CHN 2 )

Author(s) -

Lu Yang,

Huang Chuyu,

Liu Chao,

Guo Yong,

Chen QingYun

Publication year - 2018

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201800325

Subject(s) - chemistry , porphyrin , catalysis , substrate (aquarium) , combinatorial chemistry , scope (computer science) , reaction conditions , transformation (genetics) , medicinal chemistry , organic chemistry , oceanography , geology , biochemistry , computer science , gene , programming language

An efficient method for the iron(III) porphyrin catalyzed olefination of various aldehydes with 2,2,2‐trifluorodiazoethane under neutral conditions is described. This transformation was shown to have a broad substrate scope and provide the corresponding CF 3 ‐substituted alkenes in good yields. The number of equivalents of PPh 3 that is used in this reaction is crucial to the success of the olefination process. This reaction is a useful supplement to the synthetic applications of CF 3 CHN 2 .

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