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Aminocatalytic Privileged Diversity‐Oriented Synthesis (ApDOS): An Efficient Strategy to Populate Relevant Chemical Spaces
Author(s) -
Pawar Tushar J.,
Jiang Hao,
Vázquez Miguel A.,
Villegas Gómez Clarisa,
Cruz Cruz David
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800273
Subject(s) - chemical space , scope (computer science) , diversification (marketing strategy) , chemistry , diversity (politics) , drug discovery , nanotechnology , data science , computer science , sociology , business , biochemistry , materials science , marketing , anthropology , programming language
Diversity‐oriented synthesis and aminocatalysis constitute two important tools for access to important compounds. The extraordinary development in these two areas has allowed chemists to populate new regions in chemical space. As a consequence, new libraries of complex and diverse frameworks are becoming available for drug discovery. ApDOS is presented as a new concept that shows the scope of aminocatalysis for the synthesis and diversification of privileged structures.